It is tough to determine what constitutes a regular poisonous or lethal dose. Nonetheless, the lethal oral dose of codeine within an adult is noted being in the variety of 0.
e., multiple copies of your gene for cytochrome P450 isoenzyme 2D6 or significant morphine concentrations). Youngsters with snooze apnea could possibly be notably sensitive towards the respiratory depressant consequences of codeine.
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Solution shouldn't be greater if cough fails to respond; an unresponsive cough must be reevaluated in 5 times or faster for feasible fundamental pathology, like overseas system or lessen respiratory tract disorder [see Dosage and Administration (two.3)].
Indicators and symptoms of overdosage with promethazine HCl vary from gentle despair on the central nervous process and cardiovascular program to profound hypotension, respiratory depression, unconsciousness, and unexpected Demise.
This medication can dry up and thicken mucus in your lungs, which makes it more challenging to breathe and very clear your lungs. To aid stop this influence, consume lots of fluids unless in any other case directed by your physician.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric people below 6 years of age.
Due to threats of addiction, abuse, and misuse with opioids, even at advised doses, reserve Promethazine HCl and Codeine Phosphate Oral Alternative to be used in adult individuals for whom the main advantages of cough suppression are envisioned to outweigh the risks, and in whom an ample assessment of the etiology of your cough is designed.
If someone has overdosed and has severe signs including passing out or issues respiratory, call 911. Otherwise, get in touch with a poison Manage Centre at once.
Overdose of codeine in Older people has become associated with deadly respiratory despair, and the usage of codeine in small children more youthful than twelve years of age has become linked to fatal respiratory despair when applied as proposed [see Warnings and Safety measures (five.
Animal copy experiments haven't been executed Along with the drug mixture-promethazine and codeine. It's not acknowledged no matter whether this drug combination can cause fetal harm when administered to some pregnant woman or can have an affect on replica ability.
Instruct nursing moms to speak to the child's health care provider quickly when they detect these symptoms and, if they can not get to the medical professional immediately, to take the infant to an unexpected emergency place or get in touch with 911 (or nearby emergency products and services).
Most MAO inhibitors also needs to not be taken for 2 weeks before procedure with this medication. Talk to your health practitioner when to begin or cease taking this medication.
Narcotic analgesics or cough suppressants, such as codeine, should not be used in asthmatic individuals (see CONTRAINDICATIONS). Nor need to they be used in acute febrile illness Promethazine codeine syrup connected to successful cough or in Long-term respiratory condition where by interference with capacity to distinct the tracheobronchial tree of secretions would've a deleterious effect on the client's respiratory function.
If you don't Have a very drug take-back place in your area, flush any unused narcotic medicine down the bathroom. Look at your neighborhood drug retail store and clinics for acquire-again locations. You may also Check out the DEA website for locations. Here's the website link to your FDA Secure disposal of medicines Web site: